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Showing posts with label AMH. Show all posts
Showing posts with label AMH. Show all posts

Learning from my patients

Posted by nurul Friday, January 28, 2011 0 comments

I am always amazed by how smart my patients are ! It's fun learning from them and they keep me on my toes. Here's a first person guest post from one of my patients ( who is a PhD and knows more about fertility than most gynecologists do !).

She has done all her learning "on the job" - and this is an excellent example of what a highly motivated intelligent patient can do to help herself, when she sets her mind to it.

She has carried out a clinic trial on herself and done an extremely good job of it as well. In fact, based on her experience, I am now going to start studying the effect of Vit D3 supplementation on women with low AMH levels. If Vit D helps to improve their low AMH levels ( and thus their ovarian reserve ) this will be a big step forward in the treatment of these women !) It's true that one swallow does not make a summer but it's careful observation and experimentation which allows medical science to advance. The big difference here is that the experimentation was done by the patient herself - something which was par for the course about 3 centuries ago, when all scientists ( they used to be called natural philosophers in those days) experimented on themselves.

Testing summary

2 weeks post D&C bloodwork (fasting)

Test

Result

Reference range

Comments

AMH

1.1 ng/ml

1.23-7.91 ng/ml

Low- very weird especially since FSH has been consistent normal (around 6.5, with E2 22-33) and my antral follicle count was 34 in an ultrasound done 4 months ago.

Vitamin D3

(ordered on a hunch)

16 ng/ml

11-40 ng/ml

Disregarding the lab’s ranges, anything below 10 is considered severely deficient while anything below 20 is considered deficient.

Optimal values are above 40 ng/ml

Lots of references linking this one to fertility issues…I’ve been putting the literature together, could send it to you if you are interested.

Fasting Insulin

4.9 ng/ml

6-27

Fasting blood sugar was normal

Total Testosterone

84.8

9-109

Despite lab’s reference range, this value is in PCOS range for androgens. ( I think over 60 is considered in PCOS range)

I’ve had considerable variation with testosterone tests. …I’ve had 2 other tests done in the evening and there my values were low.

Interestingly, found out that testosterone levels have significant diurnal variation and are highest in the morning….repeating the test in the States, this time, fasting.

DHEAS

231

35-430

Over 200 is in PCOS range

I was the most concerned about low AMH levels. It seemed completely illogical given all my markers for ovarian reserve. On a hunch, I looked in the literature to see if there was any link between Vitamin D3 and AMH.

I found one study conducted by a group at Stanford University

http://www.ncbi.nlm.nih.gov/pubmed/19056816

This group has found that in certain organs of the body, vitamin D3 binds the AMH gene and turns on its expression. I asked the group if they had done any studies looking at AMH levels in vitamin D3 deficient woman and they said that though they were interested, it had never been explored.

Either way, I wanted to recheck my AMH after trying to increase my vitamin D3 levels. I took 60000 IU weekly for 2 weeks.

I rechecked antral follicle Count, AMH, vitamin D3, FSH and LH on the same day.



Other tests

Vitamin D3

70 ng/ml

7.6-75

AMH

5.18 ng/ml

Optimal fertility according to the lab, or PCOS range according to this website

A 4 fold increase in 2 weeks, which I found just remarkable!

FSH

5.12 ng/ml

These tests were not done on a true ‘day 3’ it was just early in my cycle though.

LH

2.93 ng/ml

Does not look like a PCOS ratio……?!?!?!

Her level of sophistication is commendable , and I just wish all doctors would engage their patients as clinical research assistants - all of us would benefit from this approach !

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How to monitor your biological clock !

Posted by nurul Thursday, April 22, 2010 0 comments

The one number all women who are planning a baby need to know !

Posted by nurul Saturday, April 10, 2010 0 comments

Many women these days are postponing having a baby in order to pursue a career. The good news is that while usually fertility does not decline too much until the age of 32, for some women the decision to postpone childbearing can prove to be one they bitterly regret later on. Fertility does decline as a woman grows older, and the problem is that it is not possible to predict the rate of decline for an individual woman. Most women are lulled into a false sense of security if they have regular period, because they assume that if their periods are regular, this automatically means that their egg quality if enough for them to make babies !

Unfortunately, this is not always true - and for some women, while their egg quality is enough for them to produce enough hormones to get regular periods, it may not be enough to make a baby ! Also, many women have very unrealistic expectations of IVF technology, thanks to all the stories of the over-40 celebs who have babies all the time ( often by using donor eggs, a fact which is very jealously guarded secret) !

How is an individual woman going to find out which category she falls into ?

Suppose you are 32 and want to postpone childbearing for another year because you have a very good chance of getting a promotion ? Is it safe to do so ? Or will this be something you will kick yourself for later on when your IVF doctor says - I wish you had come to me earlier ?

The bad news was that until now, there really was no very good test to check ovarian reserve. This often meant that most women had to just leave things upto destiny, which can be notoriously fickle.

The good news is that there is now a very good test to check your ovarian reserve !

The bad news is that most women are unaware of this test !

The good news is that this is a very simple blood test, which most labs now offer !

The bad news is that most family physicians and gynecologists are still unaware of this test and what it means !

So what's this test ?

This is a blood test for checking your AMH ( anti Mullerian hormone) levels. It can be done on any day of your cycle. The level correlates well with your ovarian reserve - the quantity and quality of eggs you have in your ovaries. Women with normal levels have good ovarian reserve; while those with low levels have poor ovarian reserve.

If you are more than 32 and want to postpone childbearing, I'd suggest you get this test done. If it's low, you might want to re-think your priorities. If it's normal, then it's fine to postpone childbearing, but do get the test repeated every year. If it starts dropping, this is a sign you might want to pay attention to your biological clock before it is too late !
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